The man, who was driving a Suzuki
Jimny, died at the scene of the crash on the A719 near Waterside, East Ayrshire.
He was travelling westbound at around 3.35pm on Sunday when the vehicle was in a collision with a Fiat Punto travelling in the opposite direction.
The man's 51-year-old female passenger was taken to Crosshouse Hospital with non-life-threatening injuries.
The 18-year-old male driver of the Punto was also taken to hospital.