The airline will operate a one-off flight of one of its A380 aircraft to carry passengers from Glasgow to Dubai on April 10.
The airline started flying from Glasgow in April 2004 and says it has carried 2.3 million passengers from the airport since then.
The Airbus A380 usually carries 525 passengers with seats in economy, business and first class, but can carry more than 850 passengers when flying with only economy seats.
It is more than 24 metres high with a wingspan of 80 metres. Emirates operates the most A380s across the world with 44 and has almost 100 more ordered with manufacturer Airbus.
Emirates UK vice president Laurie Berryman said: "As the largest A380 operator in the world, it is a historic moment to see one of our A380s take flight from Glasgow Airport for the first time.
"Celebrating 10 years in Glasgow is a landmark occasion for us and it demonstrates our continued commitment to Glasgow and Scotland, which is an extremely important passenger and cargo market for Emirates."
Amanda McMillan, managing director of Glasgow Airport, said: "Since its arrival in 2004, Emirates has been one of Glasgow Airport's biggest success stories and its decision to introduce a second daily service to Dubai in 2012 confirmed its status as Scotland's leading long-haul airline.
"To bring the A380 to Scotland for the first time will be a hugely significant milestone in our country's aviation history and an exciting day for the passengers who will have the opportunity to fly on the aircraft and the staff who have worked hard to make it possible."