The thugs forced their way into the house in Elm Drive, Johnstone, and threatened the 25-year-old man and the 20-year-old woman, with a knife.
However, the trio made off with only a two-figure sum of cash.
Police described the robbery as "absolutely terrifying" and urged any witnesses to come forward.
The young couple were sprayed in the eyes with the "incapacitant spray" during the incident.
It happened at around 11.30pm on Saturday and the suspects made off in a silver saloon car.
The first thief is described as between 5ft 5in and 5ft 9in, of slim build, and wearing a light blue zipper top, with a white logo, and light grey jogging bottoms.
The second man was wearing dark coloured hooded tracksuit top and bottoms and the third man had on dark clothing.
Detective Sergeant Gordon McRae, from Paisley CID, said: "It was absolutely terrifying for the couple involved, who thankfully were not injured.
"Although they did receive treatment at home following the spraying of a substance into their eyes.
"It would appear that the three men involved thought that there was money within the house.
"The three suspects made off in a silver coloured saloon car towards Sycamore Avenue.
"Although it was late at night, people may have seen or heard something that will help us with our enquiries.
"I would ask that they, or anyone who has information, contact detectives at Paisley Police Office."
Anyone with information is asked to contact Police Scotland on 101.