Motoring accidents claimed the lives of more people who were on foot in the area on the edges of Glasgow than the rest of Scotland, from Edinburgh northwards, and the Central Belt combined, in 2012.
Pedestrian rights campaigners responded by calling for more to be done to address the safety of people crossing roads on foot, particularly older people.
The Institute of Advanced Motorists said the concentration of such a number of deaths warranted further investigation.
Newly obtained statistics showed 18 pedestrians were knocked down and killed in 2012 in the area from Bridge of Weir, Renfrewshire, Uddingston and South Lanarkshire, to Hardgate, West Dunbartonshire, and East Kilbride, South Lanarkshire.
A total of 53 pedestrians were killed in road accidents in Scotland last year, according to a map pinpointing the
locations of each fatal collision.
The zone equates to 0.003% of the size of Scotland, or about half that of the Isle of Arran.
Keith Irving, head of Living Streets Scotland, a charity that campaigns for pedestrians' rights, said: "We know from the latest census results that Glasgow, Inverclyde and West Dunbartonshire have among the lowest car ownership levels in Scotland.
"Older pedestrians and those in lower socio-
economic groups are at greater risk of injury or fatality, which can sometimes account for clusters of incidents.
"Overall, Scotland has a poor pedestrian safety record that needs to be addressed, especially given the ageing population.
"We need investment to make all our towns and cities safe walking environments and the introduction and enforcement of proven measures such as slower traffic speeds, considerate parking and safe crossing points."
Although the cluster falls within one of the most densely populated parts of Scotland, the figure is still out of proportion with the number of people living there.
The whole of Greater Glasgow - an area measuring 142 sq miles that includes Glasgow and the seven local authorities that ring the city boundaries - is home to roughly 23% of Scotland's population.
However, official accident figures show a smaller area within it accounted for 34% of pedestrian deaths.
There were nine fatalities in Glasgow, including a 71-year-old man who was killed when he was struck by a bin lorry in the city centre in August and a 75-year-old woman knocked down near Partick train station in the West End in May.