Joe Cusker, 59, from Cambuslang, had been receiving treatment in hospital since the crash on November 29.
He died earlier today at Glasgow Royal Infirmary, Police Scotland said.
Deputy Chief Constable Rose Fitzpatrick said: "It is with great sadness that I can confirm the number of people who died when the helicopter came down on the Clutha Vaults pub has increased to 10.
"Our thoughts are with the families at this difficult time and we will continue to provide support to them, as we have done for all of the bereaved."
The news came shortly after the funerals of two of the victims were held.
Friends and family had gathered to remember Colin Gibson, 33, and Robert Jenkins, 61, who were customers in the bar when the police helicopter crashed through the roof.
Eight funerals have so far been held for the victims, with a ninth planned for tomorrow.
Mr Cusker is the seventh person inside the bar to have died. The three crew travelling in the helicopter also died.
Pilot David Traill, 51, and police officers Kirsty Nelis, 36, and Tony Collins, 43, were on board the aircraft as it returned from an operation in Dalkeith, Midlothian.
The other people who died in the bar were Mark O'Prey, 44, John McGarrigle, 57, Gary Arthur,48, and Samuel McGhee, 56.
It has not yet been established what caused the helicopter to fall from the sky, although investigators say initial evidence rules out engine or gear box failure.