The leading American burger and fries fast food chain has gained a cult following in the UK since its launch in London last year - and the 3,637 sq ft restaurant will be in Silverburn's new leisure extension, the first phase of which opens this year.
The firm also plan to open up a restaurant in Glasgow's St Vincent Street
Chris Daly, Catering Leasing Executive at Hammerson, added: "Five Guys' decision to open in Silverburn is confirmation of the centre's status as a leading retail and leisure destination in the Glasgow region. Their arrival completes the leisure extension's offer, and will significantly add to Silverburn's already strong retail success. Furthermore, it highlights the desire amongst leading brands to open flagships in Silverburn."
Richard Collier, Property Director at Five Guys, added: "Silverburn was identified immediately as we planned the expansion of the Five Guys brand in Scotland.
"It is a highly successful destination popular with consumers from throughout the region and the leisure extension creates the perfect opportunity for Five Guys.
"Our fast casual concept adds something new to the tenant mix and will appeal to existing customers and attract new visitors, driving Silverburn's appeal as both a day-out and evening destination."
Five Guys is the latest restaurant to sign for Silverburn's leisure extension, creating a total of nine new restaurants, including the recently announced Chimichanga, Carluccio's, TGI Friday's, Cosmo, Pizza Express and Zizza, in the new 100,000 sq ft leisure destination anchored by a 14-screen digital Cineworld cinema.