Three men broke into her house in the Clydeford Road area, Cambuslang, at around 12.30am on Sunday (12) and seriously assaulted her.
They threatened the woman and attacked her before making off with the sum of cash and personal items including jewellery.
She called the emergency services and was taken by ambulance to Hairmyres Hospital where she was treated for her injuries before being released.
Detectives have launched an investigation and are appealing for witnesses.
They believe the woman's house was specifically targeted.
The three men, described as white and Scottish, were wearing scarves to cover their faces.
They ran away in an unknown direction.
The first suspect is around 6ft, in his 30s and of heavy build. He was wearing a dark woolly hat and a dark grey tracksuit.
The other two suspects are both described as around 5ft 9in, in their 30s and both wearing dark clothing.
Detective Inspector Kevin Jamieson, from Cambuslang CID, said: "The victim of this frightening incident has been left traumatised by what has happened to her in her own home.
"Experienced officers are carrying out extensive inquiries, checking CCTV and undertaking door to door inquiries in an effort to trace the three men responsible.
"At the moment, we believe the woman's house was specifically targeted.
"There are extra uniformed patrols in the area to offer and additional level of public reassurance, and anyone with any concerns should not hesitate to speak to an officer.
"I would like to appeal to anyone who was in the area around Clydeford Road, or the nearby Main Street, Cambuslang around the time of the incident to get in touch.
"I would also ask anyone who saw three men hanging around or any suspicious looking vehicle in the area to contact me."
Anyone with information or who can identify the men responsible should contact Cambuslang CID on 101 or Crimestoppers where information can be given anonymously.