Caledonian University has become the first Scottish university to employ teachers to take secondary school classes on campus.
The near-£1million Advanced Higher Hub aims to support sixth year pupils into higher education.
Eleanor Wilson, director of the university's UK Recruitment and Outreach Department, which runs the hub, said: "It has been an ambitious undertaking to set up so quickly something that has never been tried before, so we are extremely excited to see the young people on campus.
"Having worked in sixth form colleges in England and seeing the benefits of those, this has been a dream of mine for a long time."
The university was awarded £952,000 by the Scottish Funding Council last December to set up an on-campus centre for the teenagers to study Advanced Highers.
The scheme is part of an attempt by the university to widen access to Higher Education for pupils who may not otherwise have gone on to university.
Caledonian already has existing links with Glasgow high schools, 15 of which are to be involved in the hub.
Pupils will visit the university's campus for six hours of teaching per subject each week.
They register as associate students and can access Caledonian's library, lab and technology facilities.
Ms Wilson added: "As well as letting them use specialist equipment it also helps prepare them for university life and lets them adjust to what it is like to be a student."
Pupils do not need to wear uniform to the hub, which has been formed in partnership with Glasgow City Council.
The 150 youngsters taking part are offered Advanced Highers in English, mathematics, chemistry, biology, computing, history, modern studies and business management.
More city pupils than ever before are staying on to S6, but fewer than one in 10 go on to study for an Advanced Higher.
In some cases this is due to a lack of a range of subjects available.
Rebecca Lavery, head of the Advanced Higher Hub, has been seconded from Coatbridge High School to oversee the scheme in its first year.
She said: "Studying for Advanced Highers gives pupils a depth and breadth of study they would never otherwise have.
"They helps pupils adjust to university study because Advanced Highers include dissertations and projects."
Eight teachers have been recruited to the hub, including Lisa McNaughton, who is now in her 14th year of teaching and has taught Advanced Higher English for nine years.
She said: "The whole premise of Caledonian's Advanced Higher Hub is that it is not elitist. It is about making a genuine pathway for students who otherwise would not have had the opportunity, yet have the ability.
"I would have loved this when I was at school. It is the chance to study in a university environment and have access to all the facilities Caledonian has to offer.
"Because each pupil is being enrolled as an associate student, they are gaining an understanding of what it is like to be at university and are interacting with their classmates from other schools. They will be taught in a university way and we have an opportunity perhaps to convince some other students who would not otherwise have considered going to university to choose this as an option."
DEAN Park, 16, of Springburn Academy, is studying Advanced Higher Biology and Advanced Higher Chemistry at the hub.
He hopes to go to university to study nursing or veterinary nursing.
Dean said: "Coming to a university campus will be a great experience. I know there is a lot of hard work ahead, but I am sure it will be worth it."
Leona Logan, of St Mungo's Academy, is planning to study dentistry.
She has five Highers and is studying for an Advanced Higher Chemistry at the hub.
The 17-year-old said: "Advanced Higher Chemistry is a must for dentistry.
"Being on campus will give me a real idea of what to expect next year."
During their induction afternoon, the pupils were given a tour of campus facilities and the hub. Their parents were also invited to visit and meet some of the teaching staff.
Pupils were welcomed by Ms Lavery.
The majority of pupils attending the hub, which opened today, live in neighbourhoods where there is a lower than average rate of applications to university.
The UK Recruitment and Outreach Department, of which the Advanced Higher is part, includes several widening access initiatives, such as the Caledonian Club, which works with parents and children.