The university has been given £6.7m from the European Regional Development Fund (ERDF) towards its £89m flagship centre.
It will bring together academics and international industrial partners to develop renewable energy options.
The announcement follows news that Glasgow construction firm Lend Lease Ltd has been appointed contractor behind the build.
Strathclyde principal Professor Jim McDonald said: "The Technology and Innovation Centre will be the fullest realisation to date of our work as a leading international technological university. The funding we have received from ERDF is an endorsement of the quality of our collaborative research."
The 25,000 square metre centre, to open in 2014, will be the cornerstone of the International Technology and Renewable Energy Zone – Scotland's hub for global green energy developments.
The triangular, nine-storey building will be constructed on a brownfield city centre site next to the university.
A total of 10% of the workers on the project will come from apprenticeship programmes.
Lend Lease executive general manager Gordon Anderson said: "We are particularly excited about working with the University of Strathclyde to bring sustainable benefit to the local community."
The Scottish Funding Council is contributing £15m to the programme, Scottish Enterprise is contributing up to £11m and the university is providing £57m.
Cabinet Secretary for Infrastructure and Capital Investment Alex Neil said: "This project can prove a real boost for our economy."
catriona.stewart@ eveningtimes.co.uk
