The MSP is expected to deliver a rallying call for Scotland to remain part of the UK in a speech to be delivered ahead of the main conference from Prime Minister David Cameron.
Ms Davidson is expected to say: "This referendum decision isn't the same as an election.
"If we don't like the result, we can't just come back in five years' time and vote again.
"It is a choice that is vital and is binding."
She is also expected to stress Union's importance to the rest of the UK and to tell the conference that Conservatives must lead the fight to "keep the country together."
She said: "We are unselfconscious in the love of our country. We have worked and strived for generations to build a Britain of which we can be proud.
"In the good times, we have shared our prosperity and our expertise.
"In darker days, we stood shoulder to shoulder with our allies and with each other.
"The Union is in our DNA."
"It's Alex Salmond who talks Britain down, saying Scots are desperate to leave.
"Well, I'm telling you now. Don't believe it.
"When it comes to this issue, Alex Salmond doesn't speak for a majority of Scots. In fact, he never has.
"But we're not complacent. In the months ahead we have a lot of work to do to hammer home to people just how much Scotland gains from being part of the United Kingdom and how much the United Kingdom benefits from Scotland being a member.
"There is no doubt the UK is greater than the sum of its parts."