Scottish Water is renewing the mains and it means the permanent traffic lights at the junction of Paisley Road West, Crookston Road and Sandwood Road will be replaced with temporary signals.
The approaching roads will also be reduced to one lane
The temporary lights will be in operation from 9.30am on Monday until 4pm on Friday.
Hillington Road South will be closed to northbound traffic between Paisley Road West and Birkhall Avenue between those hours.
Meanwhile, roadworks in the city centre will see Gordon Street closed eastbound to all traffic between Hope Street and Union Street tomorrow from 6am to 6pm.