Three men broke into her house in the Clydeford Road area of Cambuslang, at around 12.30am on Monday and seriously assaulted her.
They threatened and attacked the woman before making off with the sum of cash and personal items including jewellery.
She called the emergency services and was taken by ambulance to Hairmyres Hospital, East Kilbride, where she was treated for her injuries before being released.
Detectives have launched an investigation and are appealing for witnesses. The three men, described as white and Scottish and who made their getaway on foot, were wearing scarves to cover their faces.
The first suspect is around 6ft, in his 30s and of heavy build.
He was wearing a dark woolly hat and a dark grey tracksuit.
The other two suspects are both described as around 5ft 9in, in their 30s and both were wearing dark clothing.
Detective Inspector Kevin Jamieson, from Cambuslang CID, said: "The victim of this frightening incident has been left traumatised by what has happened to her in her own home.
"Experienced officers are carrying out extensive inquiries, checking CCTV and undertaking door-to -door inquiries to trace the three men responsible.
"At the moment, we believe the woman's house was specifically targeted.
"There are extra uniformed patrols in the area to offer an additional level of public reassurance, and anyone with any concerns should not hesitate to speak to an officer.
"I would like to appeal to anyone who was in the area around Clydeford Road, or the nearby Main Street, Cambuslang, around the time of the incident to get in touch.
"I would also ask anyone who saw three men hanging around or any suspicious looking vehicle in the area to contact me."
Anyone with information or who can identify the men responsible should contact Cambuslang CID on 101 or Crimestoppers where information can be given anonymously.