Norie Mackie was at the helm of Govan's Pearce Institute for nine years and saw through key developments.
But after a reshuffle at the Govan Road centre, his chief executive post was made redundant.
Mr Mackie said: "I was very sorry to leave the PI after several years. I remain committed to community groups across Glasgow and beyond and am looking to become involved in new projects."
The institute, which opened in 1906, was gifted to the people of Govan by Lady Pearce in memory of her husband, Sir William Pearce, former owner of the Fairfield Shipyards and Govan's first MP.
More than 40 third sector organisations are based within the building, all sharing the aim of meeting the needs of the people of Govan.
It now offers a wide range of space, including the Mary Barbour Conference Suite, Lithgow Theatre and Macleod Hall for meetings, conferences and cultural events.
A programme of phased restoration work is continuing and already £5.5million has been spent. Among the works carried out including restoring the roof and carrying out repairs to stonework.
Reorganisation of the Institute's governance structure was completed in December 2009, with ownership of the building being transferred to a newly formed company limited by guarantee recognised as a charity.
John Flanagan, chairman of the Pearce Institute Board, said Mr Mackie's post become redundant following a restructure.
He said: "We realised we did not require a full-time chief executive and funding for the post was coming to an end. We will be looking for a part-time facilities manager.
"The on-going development of the Pearce Institute remains our priority."
Mr Mackie took on the senior management role at the Institute, which had been threatened with closure in 2001, in 2003, and led the process of regeneration. Over £5.5m of investment saw much of the building restored and upgraded.