1 Yellow Pinkie:
The arch-enemy of Secret Squirrel and based on Goldfinger from the Bond movie.
2 Baron Greenback: The toad began his life of villainy as a boy and greenback signifies his love for money.
3 Mr Burns: Charles Montgomery Burns is the evil owner of the Springfield Nuclear Power Plant and Homer Simpson's boss.
4 The Hooded Claw: With his sidekicks the Bully Brothers he tried to kill Penelope Pitstop.
5 Wile E Coyote: Has been the prime antagonist of Bugs Bunny and the Road Runner.
6 Doctor Doofenshmirtz: Doof is the bumbling evil genius in Phineas and Ferb.
7 Skeletor: Once a human before he was scalded with acid, he is now the enemy of He-Man in Masters of the Universe.
8 Bluto: Muscular character, he is Popeye's rival for the affections of Olive Oyl.
9 Plankton: Shady character who runs the Chum Bucket restaurant in SpongeBob SquarePants.
10 Gargamel: The evil wizard trying to capture the Smurfs.