The match at the Generali Arena is Chelsea's first away fixture in Europe since Roberto Di Matteo was sacked following the holders' exit from the Champions League group stages.
"This is a massive city, massive club and a massive competition," Benitez said.
"We are really pleased to be here. Obviously, you cannot change things. The Champions League is a massive competition, but the Europa League is also a massive competition.
"We know it will be tough. It's against a great team, a great club and a great city."
The Blues are at near full strength, with David Luiz suspended, Demba Ba ineligible and Victor Moses and John Obi Mikel rested following their African Nations Cup win with Nigeria.
Captain John Terry is still the main fitness concern for Chelsea after missing the 4-1 Barclays Premier League win over Wigan with an inflammation on his knee.