And the move opens the door for former Spurs boss Harry Redknapp to take over.
The club's official Twitter account confirmed the news, saying: "Queens Park Rangers Football Club has terminated the contract of manager Mark Hughes with immediate effect", with a statement from the club following.
It read: "Queens Park Rangers Football Club has today terminated the contract of manager Mark Hughes with immediate effect.
This decision has been taken after careful consideration by the Board of Directors, following numerous meetings over the last few days.
"The Board of Directors wish to thank Mark for his commitment, hard work and dedication in his 10 months in charge.
Mark has shown integrity and professionalism throughout his time here, but ultimately the circumstances we find ourselves in have left the Board of Directors with very little choice but to make a change.
The Board will now be working actively to put a new managerial structure in place as soon as possible.
Mark Bowen and Eddie Niedzwiecki will take charge of QPR's trip to Manchester United in the Barclays Premier League tomorrow.
The club will be making a further announcement in due course."
QPR are currently bottom of the Premier League, having gained just four points from their opening 12 fixtures, with last week's abject 3-1 home defeat to Southampton the final nail in Hughes's coffin.