McCulloch's second-half double against Queen's Park helped fire the Ibrox club into pole position in the title race.
A 2-0 home win put Ally McCoist's men on top of the table for the first time in what has been a difficult 2012/13 campaign.
And the Gers captain, who took his tally for this term to 13 with his brace, is determined the Govan club remain there.
He now wants Rangers to bury their hoodoo on the road with a victory over Clyde at Broadwood on Sunday.
The Light Blues have drawn with Peterhead, Berwick and Annan, and lost to bottom-placed Stirling Albion on their league travels this season.
McCulloch said: "Having gone top we now have to stay there and for that reason this weekend's match is massive for us.
"We are well aware that our performances and results on the road so far have been nowhere near good enough.
"We have got a lift from going top of the table. I think if we can get a result against Clyde we can kick on."
McCulloch revealed Rangers manager McCoist had not focused on the Ibrox club's dire away form during the two-week international break.
But the 34-year-old expects his gaffer to concentrate heavily on where they have gone wrong on their travels in the coming days at their Milngavie training complex.
He added: "The defeat to Stirling Albion was deeply disappointing, of course, and totally unacceptable for a club like Rangers.
"But, to be honest, we haven't dwelled on it. It hasn't played on our minds. We have just got on with our work in training as normal.
"The manager will be concentrating on our shape and how we are going to play in the next away game against Clyde."
Many Rangers fans feel having too many young players in the team has been responsible for their poor run away from home.
But with Andy Little returning from injury in the second half of the Queen's Park game, McCulloch feels the Gers can have no excuses against Clyde.
He said: "We have got experience in the team now with myself, Andy, Neil Alexander, Lee Wallace, Ross Perry, Ian Black and Dean Shiels.
"It was good to see Andy return at the weekend. He has been prolific for us in the games he has played this season. He can also be used in a variety of positions.
"Hopefully, we can get a good week of training under our belts and be well prepared and in good shape when we come to play Clyde."