Sean Lineen's men are sitting in the fourth and final play-off slot with just four games left to play of the regulation season.
The Blues' 26-14 defeat by Scarlets last time out has seen them drop seven points behind Warriors in the race for the play-offs, and Pyrgos has no doubt that will make them doubly dangerous in the 7.35pm Firhill kick-off.
But, with Glasgow set to be boosted by the return of their Scotland players, Pyrgos has no doubt Warriors can claim a vital victory over the big-budget Welsh province which would mean Glasgow claiming a double over the Blues.
The Warriors scrum-half said: "We are under no illusions as to how tough this game will be. They slipped to the home defeat by the Scarlets that has badly dented their play-off ambitions, and that means they will see Friday as an absolute must-win.
"We also beat Cardiff at their patch back in October and no side likes to lose home and away to any opponent. So, the one thing you can guarantee about Friday night is that Cardiff will come to Firhill to throw everything at us.
"From that point of view, although we were pleased with our win over Aironi, we are going to have to lift things a level if we want another win. We know the target for us is to win every match and see where that takes us. There is little margin for error."
Pyrgos collected the man-of-the-match award for his outstanding display against Aironi, but is likely to face demotion to the bench with the return of Scotland No.9 Chris Cusiter.
However, the 22-year-old was philosophical about being displaced following a season's best display. Pyrgos said: "I just try and produce the best rugby I can every time I pull on a Glasgow shirt and try to improve from game to game. Chris is a tremendous scrum-half and a seasoned international, and it is a great boost to have him back. So that is a call for Sean [Lineen], and I have learned so much from Chris this season and will continue to try and do so."
With an impressive home gate of 4,110 turning out for the visit from the back-marking Italians, Pyrgos is hoping an even bigger crowd will roar Glasgow on to the double over the Blues.
He said: "The crowd were great against Aironi and really stayed voluble until the end. But this game with Cardiff is even more important and, with our inter-nationals back, hopefully we can get over 5,000 on Friday."
lWales coach Warren Gatland is reported to have received an offer to lead the British and Irish Lions on their tour of Australia next year. It is understood he was interviewed for the role of head coach along with Ireland's Declan Kidney and Scotland's Andy Robinson.
The 48-year-old New Zealander is the outstanding candidate for the role after guiding Wales to a second RBS Six Nations Grand Slam in his four-year tenure and has previous Lions experience having been part of the backroom staff for the 2009 tour to South Africa.