And leading the way was Manchester United manager Sir Alex Ferguson who cheered his countryman on to victory.
He said: "I'm really proud for the boy. That was a real test of a champion for me. I love watching tennis.
"It was more nerve-wracking than a Premier League match. I'm usually in control of my own situation but I wasn't in control last night."
World No.1 and friend Rory McIlroy, Formula One superstar Jenson Button and boxing hero David Haye also all saluted Murray's success.
Also, one of the biggest names in tennis was just as quick to offer his congratulations today with Murray's childhood hero, Andre Agassi, joining in the celebrations.
McIlroy, who has been to cheer on Murray at Wimbledon in the past, said: "Massive congrats Andy Murray. The first of many and well worth the wait."
Button said: "Congratulations Andy Murray for winning the US Open, top effort."
And Haye, added: "Get used to seeing Andy Murray winning Grand Slams. This is how it's going to be from now on – congratulations Andy 'The Machine' Murray."
Agassi was pleased to see Murray finally win a Grand Slam.
He said: "Well deserved – congratulations to the US Open Champion Andy Murray."