With the aid of their fair share of refereeing calls, the Lanarkshire side put on a truly impressive performance at the Port Glasgow Community Stadium that left little doubt of the threat they can pose.
"It's not a myth to say a gulf exists between Super Premier League clubs and the rest of Junior football throughout the West Region," said Macca.
"I believe my side demonstrated that in running out comfortable winners and playing some great stuff until thinking the game was in the bag and taking our foot of the gas in the last 10 minutes.
"Yes it would be true to say we probably had the rub of the green refereeing wise but Shotts have been victims on so many occasions this season that one game goes nowhere near redressing the balance."
A healthy visiting support watched on as the cup holders pass up a few early scoring snips before getting their noses in front through Alan McKenzie's point-blank range header in 25 minutes.
Greenock were quite clearly perplexed by referee David Kirkland who was not shy in awarding a host of calls against them. He had already three players yellow carded and assistant boss Martin Campbell ordered from the dug-out prior to his surprise 40th-minute dismissal of Ross Kearns for a challenge that felled McKenzie just outside the penalty box.
That award allowed Andy Scott to demonstrate his free-kick expertise with a fine shot high past Nock goalkeeper Davie McFarlane for 2-0.
Shotts showed no mercy and duly put the game out of reach of their hosts with a controversial third goal just a few minutes later, Tony Jaconelli's handball evading the whistler's attention before he lashed into the net.
It was no real surprise that Greenock's players loudly protested against that call, but the yellow card flashed at John Boyd for stating his views only made things worse for the home support.
Their voices were not heard again until well into the second half and there was a clear ring of disbelief about them as loud penalty claims were turned away when substitute Kenny Mackay was hauled down by a despairing tackle inside the box not long before Shotts went upfield to earn a spot kick of their own.
It was an easy decision as Tom Docherty scythed down Shotts' Colin Williamson as he looked to net a Hugh Kerr effort that had rebounded off the upight. Tam Hanlon scored from the spot.
however, slackness in the visiting ranks over the closing stages let Nock to put a better complexion on the scoreline with late scores from Docherty and Mackay.
A controlled but bitterly disappointed Greenock boss Stevie Mooney was blunt in his summations.
"I think it would be correct to say every major decision went against my players. and it's to their credit that they kept the lid on their frustrations to the extent they did," he said.
"It only makes me laugh when people talk about breaks evening themselves up over a match or a season.
"Because there were no swings and roundabouts out there and one man has literally knocked the stuffing out of us."
The biggest Emirates Cup upset occurred at Saracen Park where Ashfield lost out 1-0 to Davie Wilson's goal for Ayrshire District League minnows Ardeer Thistle.
Shettleston raised a few eyebrows in eliminating Tayport 3-1, while Petershill overcame last season's East Region champs and beaten Emirates semi-finalists Bonnyrigg Rose 6-3.
At nearby Newtonrange Star, an early Kier Millican goal proved decisive as Auchinleck Talbot triumphed 1-0 while Camelon came unstuck in a 3-3 home draw with Thorniewood United.
Cumnock and Rutherglen Glencairn racked up convincing 6-0 vitories, while Rob Roy, Irvine Meadow, Yoker and Beith all progressed into the next round.