The flame-haired midfielder is a major doubt for Sunday's Sectional League Cup final against Ayrshire rivals Irvine Meadow.
Spence watched in horror as a knee swelled up like a balloon as a result of an innocuous training ground challenge on Tuesday night.
And the odds are stacked against him making the starting line-up for the showdown at Bellsdale Park.
But the one-time Gretna signing – scorer of two goals in last season's final victory over Medda – is refusing to accept his chances of picking up a fifth Ardagh Glass winner's medal is a lost cause.
He said: "The injury came about in a gentle kickabout game at training when my studs stuck in the turf and all my weight went in the other direction.
"It was a sore one at the time and right away I thought my cup final chances were gone.
"And I felt ten times worse on Wednesday morning when I woke up with my knee full of fluid, feeling very painful and twice its normal size.
"Our physio Andy Callaghan feared the worst, but he cheered me up no end by saying I could be back in full training by next midweek.
"So now I'm determined to have a go at making Sunday's game.
"Andy thinks it's coming too soon for me, but at the same time he's prepared to give me further treatment sessions tonight and tomorrow to help my recovery.
"The gaffer, Tommy Sloan, is also willing to delay naming his team to give me as much time as possible.
"I'm desperate to take part, especially going up against my local team and with the great rivalry existing between the clubs. However, I won't cheat on my team-mates or the gaffer by declaring myself fit when I'm not."
A Spenny call-off would not be calamitous for Bot boss Sloan, even though he is resigned to being without club skipper James Latta (awaiting knee surgery) and tough defensive ace Martin McGoldrick (broken foot).
Such are his Beechwood Park resources that Dwayne Hyslop or Kyle Faulds could easily deputise for Spence, while Graeme Wilson and Ray Montgomerie might figure in a right-flank role.
Auchinleck's strength in depth is in stark contrast to that of opponents, Medda, where gaffer Chris Strain is faced with a selection crisis, with a host of players set to be posted missing.
Latest name to add to an ever lengthening non-starters' list is his own son Chris, who is set to be sidelined for a month with an ankle injury.
A cartilage problem rules out striker Mick Hughes while J.P McKeever, Davie Hamilton , Adam Strachan and Kieron Burns are all unavailable.
Strain had also discounted midfielder Stevie 'Becksy' Miller from his plans after he damaged an eye socket in a mid-air collision with team-mate Hamilton against Newmains and was advised by doctors to avoid "contact sport" for a week.
But this morning the former Pollok and Maryhill battler was not ruling himself out.
He said: "I had to laugh at the advice given by the hospital because the one thing you cannot avoid when playing Auchinleck Talbot is plenty of physical contact.
"Even Colin Spence is not averse to letting you know he's about. He's got everything in his locker and is as good an opponent as I've come up against in the Juniors. So it would be a significant boost to ourselves if he misses out on a place in the final."
On his own chances of playing, Becksy added: "My vision has improved no end and my head is now clear, so I'm keen to help the team out, but I'll wait until nearer to kick-off time as a precaution.
"This is our fourth Ardagh final against Talbot in the past seven years and they've won the previous three, so I'd love to redress the balance.
"And, by all accounts, Sunday will see them going for the 100th trophy win in their history and everyone at Irvine Meadow would prefer that milestone is not reached against us."