There are three changes in the pack and one behind the scrum, with Lineen continuing to rotate his hookers and Dougie Hall selected to start the clash.
In the second row, Al Kellock has been made available by Scotland and will captain the side. Calum Forrester will start at blindside flanker.
And in the centres, Federico Aramburu will partner Alex Dunbar, with Troy Nathan forced to sit the game out with a back injury.
Lineen said: "It's a marker of our strength in depth that, even with 10 backs unavailable, there's still plenty of quality and tenacity behind the scrum. We're obviously really pleased to have Al available.
"Every game left this season is one where the stakes are raised and the players are excited by the challenge of doing something we've never managed before – winning away to Ospreys."