The Windyhill golfer lines-up in the Challenge Tour's season-ending Apulia San Domenico Grand Final in southern Italy and is targeting a grandstand finish.
McArthur, 33, is 44th on the second-tier circuit's money list and needs a place in the top 21 to secure promotion to the top table.
The first prize up for grabs is more than £50,000 and McArthur, a winner on the Challenge Tour in 2008, is aiming to go for broke in his late bid to hit the jackpot.
The ex-Scottish Amateur champ said: "The target this week has to be a win or second place. I feel like I've been playing decently these last few weeks and it's a case of going for it.
"This will be my fifth time at the Grand Final and previously I've been much higher up the rankings and maybe worried about what those around me were doing. This week there's nothing to defend so I just have to get in amongst it."
McArthur is joined in the elite, 45-man field on the Adriatic coast by Clydebank's Scott Henry and Greenock man Chris Doak.
Henry has already sealed a European Tour card after a stunning win in last month's lucrative Kazakhstan Open, a result that helped him rise to ninth on the Challenge Tour rankings.
Doak is also set for the main circuit in 2013 after bagging the Allianz Challenge de Lyon title earlier this month to move up to 10th on the money list.
However, Henry and Doak will both be aiming for a final flourish this week as they try to climb further up the order of merit and gain a better category for the European Tour next season.