The Argentinian world No.7 enjoyed one of the best weeks of his career when he beat Murray and Novak Djokovic back-to-back at the BNP Paribas Open last week, the first player to get the better of the world No.1 this year.
Grass has not been Del Potro's strongest surface but he showed his potential last summer when he beat Djokovic to win the bronze medal at the Olympic tournament at Wimbledon.
The 24-year-old said: "I like to play on grass, and at the AEGON Championships you feel like you are at home. They provide some great facilities for the players and it's a very good tournament.
"I have a fantastic memory from last year when I won the bronze medal at the Olympics. It was a magnificent experience for me. I had never played at an Olympics before so it was a big moment for me and my country.
"To win on grass at Wimbledon as well made it an even bigger moment. I think that if I play my best tennis I have a chance to win a Grand Slam tournament on grass."