Both beleaguered nations are desperate to record a positive result to kick start their already-struggling World Cup qualifying campaigns.
Two games in, the heat is on as the dream of Rio 2014 is in serious danger of disappearing over the horizon.
With draws against Serbia and Macedonia, Scotland are in a marginally better position than pointless Wales, whose 10 men lost 2-0 at home to Belgium then crashed 6-1 in Serbia. But Craig Levein's players are now embarking on the first leg of an away double-header, and must take something from Cardiff before they head to Brussels a week tonight.
Joe Ledley is in the perfect position to gauge both camps. An integral part of the under-achieving Welsh squad, he is based in Glasgow and knows only too well how heavily expectation has been pressing down on the shoulders of Levein and his players.
The midfielder's assessment of the situation is unequivocal – winning has to be the aim for both sides. Ledley said: "We're coming off a bad defeat against Serbia and looking to put things right, and Scotland need a win.
"So both teams will be fired up to take all three points. A draw would be worse for Scotland than for us. It would be nice for us because we'd at least then have a point on the board, but I think both teams will be set out to go for the win."
Ledley has been a frustrated bystander as Chris Coleman's tenure as Welsh boss has got off to a hugely-disappointing start.
The feelgood factor carrying them up the Fifa rankings was cruelly whipped away with the tragic death of previous manager Gary Speed.
Now the momentum he built up has been thrown violently into reverse, as defeats against Belgium and Serbia confirm.
"I missed those games through injury, but I know the players weren't happy with the results," said Ledley.
"The boys did alright against Belgium, given they are one of the favourites for the group.
"They've got a team full of Premier League players. Then it was very difficult away from home in Serbia. So we have to pick ourselves up again as we're under a little bit of pressure."
Ledley and Celtic team-mate Adam Matthews have an extra incentive to come away from this game with the bragging rights intact.
They know Scott Brown will show no mercy if Scotland prevail.
"It's going to be a fantastic battle, James Forrest and Adam on one side, and me and Broonie in the middle, if we're all playing," said Ledley.
"Hopefully, we can get into Broonie's head. If there's a 50/50 to be won, both of us will try to win it. That's what we're like. We play to win and we're both committed players.
"And it will be the same with James and Adam, they'll both be up for it."