Although not expected to be a runner in the race stable companion Synchronised won last year, it is more part of his preparation for the Grand National.
O'Neill said: "I've got him in the Pertemps, but there will be 28 runners there and I wouldn't want anything to happen to him.
"I'm not sure where we'll go, but the plan is really Aintree. He could well run at Cheltenham and there would be fewer runners in the Gold Cup so it might be an option."
There will be plenty of other runners for the stable in the handicaps, but another leading fancy is Taquin Du Seuil, winner of the Challow Hurdle at Newbury.
O'Neill added: "He'd be my best chance in the two-and-a-half Neptune, but it's a hot race."
About old stager Albertas Run's chance in the Ryanair Chase, the trainer said: "He's just okay.
"All being well, he'll run and he's healthy, but is he as enthusiastic? That remains to be seen."