RafaEL Nadal will miss two US Open tune-up events due to a wrist injury that has put his status in doubt for a title defence at the year's final Grand Slam.

Nadal, who suffered the injury during practice, will have to wear a cast on his right wrist for two-to-three weeks, forcing him to withdraw from next week's Rogers Cup in Toronto and the following week's Cincinnati Open.

"Depending on the evolution of the injury that will be carefully followed by the doctors, including MRI tests, it will be decided then the return to competition, initially scheduled for the US Open," Nadal's publicist said.

With Nadal's withdrawal, Andy Murray moves into the No.8 seed, giving him a first-round bye in Toronto.