The 39th staging of this biennial golfing bunfight swings in action this morning and it is set to be a Titantic tussle.
Jose Maria Olazabal's European crusaders have arrived on US soil as the defending champions and are aiming to plunder the famous gold chalice for a fifth time in the last six meetings.
In the imperious Rory McIlroy, the visitors have a world No.1 who continues to grow in stature with every tournament. Europe expects and with good reason.
The days of an inferiority complex in this transatlantic tussle have been battered out of bounds in spectacular style.
The fact that the shimmering mantle of world No.1 has been held exclusively by four Europeans, namely McIlroy, Luke Donald, Lee Westwood and Martin Kaymer, since the beginning of last year simply highlights this sense of confident, global conquering.
That quartet will all be involved this weekend as will Graeme McDowell, the former US Open champ who gained the winning point on that manic Monday at Celtic Manor in Wales two years ago when torrential rain ensured that the event would run into an extra day for the first time since its inception in 1927.
It was tight then – Europe won by a single point – and you can expect an equally close clash this time.
To the delight of the Scots, Paul Lawrie, who racked up an impressive haul of 3.5 points from a possible five during his debut in 1999, is back in the fray after a 13-year absence.
Then you have the likes of Sergio Garcia and Ian Poulter, two bubbly characters for whom the Ryder Cup stokes the competitive fires like no other event.
Down in the dumps earlier in the year, Garcia emerged from the doldrums at just the right time with his win in the PGA Tour's Wyndham Championship last month.
The Spaniard simply relishes the cut and thrust of the contest and is truly a team player.
Eight wins and a half from nine foursomes games and five wins and two halves from 10 fourball ties since his debut at Brookline in 1999 underlines that particular observation.
Momentum is everything in a Ryder Cup and the visitors certainly have plenty of that thanks to the morale-boosting wins of McIlroy, Garcia and Lawrie on various stages in recent weeks.
Peter Hanson, the Swede who made his debut at Celtic Manor in 2010, added to the general feelgood factor by winning the Dutch Open at the start of the month.
Even Kaymer, who has been badly out of sorts and just managed to hold on grimly to the final automatic qualifying position on the points list, has shown signs of encouragement with a top-five finish in the Italian Open a fortnight ago, his best result since last November.
The set-up of the Medinah No3 course, the stage upon which the Ryder Cup rumble will be played out, should add to the spectacular spectacle.
The big guns are already being moved into position. Bereft of any rough, there will be plenty of opportunity to blast away from the tee with the driver while the risky recovery shot will be a tantalising option for those who stray from the generous fairways.
To these enticing ingredients, you can throw in the added spice of the matchplay format, a type of golf that has always encouraged artistry and bravery and one that rewards those flashes of inspiration and invention that can turn a tie.
Until Europe's golfers enjoyed their recent resurgence, the US players had, by and large, been in better form.
The hosts have the weight of history in their favour with 25 wins to Europe's eight and GB&I's three (with two draws) while the away team has only won once in the last seven matches.
Not so long ago, observers where asking where the next generation of American golfers were coming from?
Those questions were answered by the likes of Keegan Bradley, Bubba Watson and Webb Simpson who have stepped up to the plate and have won the US PGA, the Masters and the US Open respectively in the past year.
With the experience of Tiger Woods, who won two Majors at Medinah, Phil Mickelson, Jim Furyk and Zach Johnson, team captain Davis Love III has a formidable mix at his disposal
With 24 of the world's top 35 all on show this weekend, the Ryder Cup will be a true clash of the Titans.