Alan Archibald's side suffered their heaviest loss of the new season at Firhill as the Dons eased to a 3-0 win courtesy of goals from Calvin Zola, Peter Pawlett and Josh Magennis.
The Dons defeat is only the second time Thistle have been turned over on league duty since Archibald replaced Jackie McNamara in February following their 1-0 reverse at Fir Park last month.
The Jags have to wait until the visit of Kilmarnock this weekend to set the record straight and defender O'Donnell is determined the Firhill side will prove a point after a rare no-show.
He said: "It is just one game. In the Premiership, we are going to get punished if we are not all on our game in every game and that is what happened on Saturday.
"It is never nice to lose. We could have done with a midweek game this week to get it out our system and give us a chance to bounce back quickly.
"We have an opportunity to do that against Kilmarnock this weekend and hopefully we can get our first home league win of the season as well. It is another big game for us, they all are.
"We want to make Firhill as much of a fortress as we can.
"We didn't do that on Saturday but hopefully we can make a start against Kilmarnock."
Thistle were never at the races on Saturday as Derek McInnes' side stormed to a convincing victory, with Man of the Match goalkeeper Scott Fox pulling off a number of stops to prevent the scoreline getting worse for the SPFL Premiership newcomers.
The Dons showed why they have been tipped to finish best of the rest behind champions-elect Celtic this season with an impressive display.
But O'Donnell knows Thistle still let themselves down with a poor performance.
He said: "It was much like the Motherwell game, especially the first half through there.
"We didn't seem to have an answer to Aberdeen, which was disappointing. We weren't good enough all over the park.
"Foxy made some great saves but, outwith him, I wouldn't say many people got pass marks.
"Aberdeen are a good side. I thought they would finish second this year but we should be competing more than that.
"Hopefully, we can bounce back this week against Kilmarnock.
"Aberdeen played well. I didn't think they created much in the first half but they still scored two goals.
"We came out in the second half and tried to mix it up but it wasn't coming off for us.
"It is a sore one to take. We need to take our medicine.
"To get beat 3-0 is disappointing but I don't think they battered us. They took their chances and they stopped us creating chances.
"That was disappointing because normally we are good going forward and we create chances to score. That didn't happen on Saturday unfortunately."