The Warriors No.9 has been starved of Six Nations action during the first three rounds of the tournament thanks to Greig Laidlaw's impressive half-back partnership with Ruaridh Jackson.
Pyrgos was a second-half replacement for the Edinburgh ace in the opening two games with England and Italy, but failed to enter the fray in the gutsy 12-8 victory over Ireland a week past on Sunday.
But with Scott Johnson's men sitting joint second with the Welsh and still in with an outside chance of the title, Pyrgos is desperate to play and has no doubt his call to arms against Cardiff could bolster his hopes.
The 23-year-old said: "It was massive for me to get the game time against Cardiff considering I didn't make it off the bench against Ireland. Being in the Scotland squad is fantastic and the mood in the camp is tremendous and really positive.
"But when you have prepared all week and you are not involved in the match it is tough.
"So it was very important for me to get the run out on Friday and hopefully that has given me a good platform to have a solid week in training and help make sure the Scotland coaching staff know I am ready to do a job if called upon on Saturday.
"To be involved with a Scotland team still very much alive in the Six Nations is huge. We know if we beat the Welsh we can stay in it to the final match and that is the target.
"They still have England at home on the final day and they know if they beat us they can win the tournament. So Saturday will be about two sides giving it everything to get the win."
Pyrgos was in no mood to underestimate the importance of last Friday's bonus-point victory over Cardiff which set a new Glasgow record for consecutive victories at seven.
He said: "It was massive to beat Cardiff and go into the three-week break on top of the table, but at the same time there is no way we can afford to get carried away.
"When we come back we go to Leinster and that is a huge game. Then the following Friday we have Munster at home.And we still have the other sides in contention such as Ospreys and Scarlets to come.
"Then we end the regulation season at Connacht where Dan Parks is now pulling the strings. So there is no way we can get carried away with all of that to come.
"But what Friday has done is put the pressure on Leinster to come out on March 23 and have a real go at us. It is a must-win game for them, but we will be treating it the exact same.
Meanwhile, Johnson has recalled Euan Murray and Alasdair Strokosch to his squad.
Murray, the 32-year-old tight-head prop, and 31-times-capped Perpignan back-row forward Strokosch both return to the group after missing last month's win over Ireland.