The 23-year-old will skipper Warriors at openside as he bids to lead Glasgow to six straight victories for the first time ever in their league history, while a home win would also consolidate Glasgow's status in the PRO12 top three going into the international break.
A fired-up Fusaro said: "The chance to make a bit of history is something that is a massive motivation for tonight's game. But while that is the case, we have to concentrate on doing the best job we can against Dragons.
"They are a very tough, physical side who will be smarting from a frustrating loss at home to Ulster and they will be coming to Scotstoun to prove a point. But it is vital to us in front of our fans that we produce a victory.
"We have given ourselves a great platform into this one with the win at Treviso and we have to make sure we make the most of that by getting the win.
"It is the second time I have skippered the side out after doing so against Zebre and I want to keep my 100 per cent record."
He added: "We were all very frustrated with the Ulster loss, especially in front of a full house. The support is due a win and we are determined to produce one."
Head coach Gregor Townsend has made seven changes from the team which defeated Treviso, with skipper Al Kellock one of a number missing on Scotland duty ahead of the first EMC Test against New Zealand.
Glasgow: Murchie; Seymour, Dunbar, Nathan, Paris; Wight, Matawalu; Reid, Hall, Cusack, Ryder, Swinson, Harley, Fusaro, Strauss.
Meanwhile, Scots No.8 David Denton hopes to build on his first season as an international by ending his second touring Australia with the British and Irish Lions.
The 22-year-old was one of the few Scotland players to enhance their reputations in a poor 2011-12 season, which finished on a high with the June tour wins in Australia, Fiji and Samoa.
Denton missed the trip with an ankle injury and has made a slow start to the season with Edinburgh.
He also knows to fulfil his ambition of a Lions place that he must first break into the Scotland team, a task made all the tougher with Kelly Brown named as captain this week.
Denton, who like Brown can play at No.8 and blindside flanker, said: "A lot of people have been talking to me about second-season syndrome. It's a massive goal of mine to make sure that doesn't happen."