The New Zealand-born wing qualifies for Scotland through his grandparents
Interim head coach Scott Johnson said: "Sean is very proud to be pulling on the Scotland jersey for the first time.
"His family will be rapt because they raised him in New Zealand always reminding him of his Scottish heritage, getting up in the early hours of the morning to watch both Five and Six Nations games on TV.
"He's shown he can play with the best of them and the impact he's made since arriving at Glasgow in the autumn has underlined what we'd seen of him playing for the Crusaders in Super Rugby."
Johnson has made six personnel changes to the side that ended the EMC Tests with a 21-15 defeat to Tonga in November – a result that prompted Andy Robinson's resignation – also making one positional change.
Number eight Johnnie Beattie is recalled and Ruaridh Jackson returns at stand-off .
Ryan Grant is restored at loosehead prop following injury, while Jim Hamilton is recalled to partner Richie Gray in the second row.