Due to ongoing work at the National Stadium, the capacity at Hampden has been reduced to 42,000 for the 'original Glasgow derby' clash that will see the Light Blues play a league fixture in Mount Florida for the first time since 1957.
To mark the occasion, Queen's are planning a series of events before the game and at half-time, including a pre-match pipe band parade to accompany the teams on to the Hampden turf.
All hospitality packages have been sold out, but tickets are still available for both ends.
Before Gardner Speirs' side can look to cause a derby shock, they must first overcome the other Rangers in the division as they prepare for a trip to Berwick this weekend.
The Spiders head into the Shielfield clash third in the standings and looking to consolidate their play-off place in a congested group of promotion hopefuls.
Speirs said: "We always have good games with Berwick.
"We drew with them at Hampden earlier on in the season.
"I am sure we will be in for another tough test this weekend.
"Rangers seem to have got into their stride now and it will be difficult for anyone to prevent them stretching that lead.
"But there are a number of teams just behind them with an awful lot to play for, ourselves being one of them."