But the Buddies star insists Danny Lennon's side have their own point to prove as they look to kill the Hoops' cup dreams for the second time this season.
The Saints have already knocked the SPL leaders out of the Scottish Communities League Cup at the semi-final stage and host Neil Lennon's side this weekend aiming to book a last-four berth in the Scottish Cup.
Defeat at Hampden ended Celtic's chances of a domestic clean sweep this season and McGinn is determined to pile more misery on the Hoops.
He said: "I am sure Neil Lennon will give them a shake to try and get some revenge, but we have to try and cancel that out and play our game.
"We need to prove that it wasn't a one-off. We played very well that day and we will have to play well again if we are to win this weekend.
"We had a belief going into the game at Hampden that we could win it and I don't think we would have won the game without that confidence.
"We have to take that into Saturday and hopefully we can prove that it wasn't a one-off result.
"We want to finish as high up the league as we can, but the cups have been great for us so far this season.
"We have played at Hampden already and we want to try and get there in the Scottish Cup now."
The Celtic clash not only gives St Mirren the chance to take another step towards a Hampden semi-final return, it allows McGinn to once again go toe-to-toe with a star studded Hoops midfield.
The youngster earned rave reviews for his impressive showing in January and hopes he can once again emerge with top marks.
He said: "It is a great experience for me every time I play. I am playing against experienced guys and that can only benefit me in my career.
"The semi-final performance gives me a lot of confidence that I can play at this level and hopefully I can replicate it on Saturday."
While Celtic go into the cup tie on the back of a loss to Motherwell, St Mirren are in high spirits after a 2-0 win over Hearts.
An early Paul McGowan penalty and superb strike from Graham Carey clinched the points, with the Republic of Ireland star grabbing the headlines for his long-range thunderbolt.
McGinn said: "Graham's technique is unbelievable. It was a great goal. I was shouting at him to shoot, but I don't think he heard me.
"Thankfully he had a go and it was a great goal. He has got that kind of goal in his locker, he does it all the time in training.
"He does try that kind of thing a lot and it is great when you see that hard work paying off."
Victory over the Jambos, who sacked boss John McGlynn just hours after the SPL clash, moved the Buddies up to 10th place in the table.
They will face the Tynecastle side again on League Cup final duty later this month and McGinn knows they must keep their game at a high level.
He said: "It wasn't our best performance, but we managed to grind it out thankfully.
"We haven't been doing that well in the league recently so it was important that we got back on form.
"The gaffer made a few changes on Tuesday night to give some of the boys a rest, but the guys that came in did well.
"It shows that we have got good competition for places for the cup final."