Trainer Mick Channon runs two in the race, with Irish 1,000 Guineas heroine Samitar his clear first string.
However, this looks a tricky contest to judge on paper, with question marks over the likes of Newmarket victor Homecoming Queen, and even Samitar, in what is something of a jumble of form.
Laugh Out Loud looks a progressive filly and could be the type to spring a surprise after having landed a Chantilly Group 2 last time.
That two-length verdict looks pretty good and she had won a York Listed event and two of her first three starts, with her only unplaced run coming when eighth in the 1,000 Guineas at Newmarket.
Channon perhaps threw her in at the deep end that day and Laugh Out Loud took a strong hold which she then paid for when tiring.
She has 8lb to find with Homecoming Queen on the ratings, but has improved in recent weeks, and with Frankie Dettori in the saddle, Laugh Out Loud must be rated a real contender.
Frankel delivered a virtuoso performance in the Queen Anne Stakes on the opening day and it is now time for his brother Noble Mission to step up to the plate in the King Edward VII Stakes.
Sir Henry Cecil has always been clear in his assertion that the siblings are different types, and Noble Mission has always appeared more of a middle-distance prospect.
Winner of two of his three starts so far this term, Noble Mission has progressed from an initial maiden victory at Newbury and can win again.