The star, who has sold more than 100 million records around the world, has been announced as the first act for Glasgow Summer Sessions.
The festival will be held in Bellahouston Park with around five shows of different genres held over ten days in August, organisers said.
Eminem headlined T in the Park in 2010 and will also perform at the Reading and Leeds festivals this year.
Geoff Ellis, chief executive of organisers DF Concerts, said: "We're delighted to announce Eminem as the first major act for Glasgow Summer Sessions.
"His performance at T in the Park and his previous stadium show at Hampden were spectacular, so this gig will be one of the events of the year.
"As it's one of the most important music destinations in the world, we're also excited about what else we have to announce for Summer Sessions and there will be more news soon."
The rapper rose to fame with the release of 1999's The Slim Shady LP and his next album, which is due to be released later this year, has been named as one of the 'most anticipated albums of 2013' by MTV, despite still not having a title or a release date.
The Glasgow concert will be held on Tuesday August 20 with tickets going on sale later this week.